Nutrient Driver is meant to be take post workout and with higher carbohydrate containing meals to help with Glucose Metabolism & Insulin Resistance, Food Cravings, Mood, Appetite Control & Weight Management, Heart Health & Cholesterol, Energy Support, Brain Health, Immune System Health, Balances blood sugar, Utilization of carbs for energy and recovery, Control appetite and cravings, Reaction to stress, Healthy cortisol levels, Improve Insulin Action and Transport of Glucose (Carbs) to muscles and is an extremely potent water and fat soluble antioxidant.
NUTRIENT DRIVER INGREDIENTS
200mcg Chromax (Chromium)
Produced by Nutrition 21, Chromax® Chromium is the premier form of supplemental chromium, backed by over 50 human trials. This trace essential mineral is essential to insulin, the body’s primary storage hormone, and helps maintain stable blood sugar levels, thus preventing the typical “crash” that follows high-carb meals..
Numerous studies show that supplementing with chromium, aids glucose management, insulin sensitivity, carb cravings, and body composition.[1,2,3,4]
Chromax chromium picolinate is different from other forms of chromium in that it has:
- A stable chemical structure*
- Superior absorption*
- Extensive clinical testing*
- Extensive safety testing*
- Extensive regulatory review*
- Always been manufactured in the U.S. according to applicable GMP standards*
750mg berberine hcl 98%
Present in numerous plants used in Ancient Chinese Medicine, berberine is an alkaloid traditionally used for its anti-inflammatory and cholesterol-lowering effects. It’s also one of the most powerful, yet underrated, nutrient partitioning supplements around.
Berberine helps regulate insulin levels and enhance glucose disposal via activation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) while simultaneously inhibiting Protein-Tyrosine Phosphatase 1B (PTP1B). This helps drive those extra calories towards building muscle and not storing fat.[6,7]
- Diabetes, Hypertension (high blood pressure) and Weight Control: Berberine Lowers Blood Glucose to help control, prevent and treat type-2 diabetes*
- Anti-aging: Enhance pathways that help to protect the brain*
- High cholesterol: Berberine has been demonstrated to reduce serum cholesterol*
- Joint problems: Berberine has anti-inflammatory properties*
100mg Banaba Extract (10% Corsolic acid)
The leaves of the Banaba plant are rich in corosolic acid, a pentacyclic triterpene well-documented to improve blood sugar regulation and enhance glucose shuttling into muscle via AMPK activation, even if you are insulin resistant.[8;9]
But that’s not all. Banaba also impacts energy balance in the body, heightens insulin sensitivity, and reduces fat accumulation.[10,11] Suffice it to say, this is a must have ingredient in any nutrient partitioning supplement!
- Balances blood sugar*
- Helps use carbs for energy and recovery*
- Potent antioxidant*
- Helps control appetite and cravings*
- May help with reaction to stress*
- Supports healthy cortisol levels*
Alpha Lipoic Acid (ALA) is a fatty acid found in the mitochondria of your cells that doubles as a potent antioxidant in the body. It aids in energy metabolism and has been shown to reduce appetite, increase energy expenditure, and enhance glucose disposal into skeletal muscle.[12,13,14] In fact, research shows that supplementing with ALA can improve glucose clearance up to 50%!
- Improves Insulin Action and Transport of Glucose (Carbs) to muscles*
- Extremely potent water and fat soluble antioxidant*
100mg Gymnema Extract
Also known as cowplant, gymnema sylvestre is a popular sugar-shuttling herb extensively researched for its ability to enhance insulin function. The results of gymnema’s actions in the body result in superior blood sugar regulation, decreased body mass index (BMI), and improved body composition.
- Balances and lowers blood sugar*
- Enhances production of insulin*
- Yang J, et al Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients . Evid Based Complement Alternat Med. (2012)
- Ikarashi N, Tajima M, Suzuki K, Toda T, Ito K, Ochiai W, Sugiyama K. Inhibition of Preadipocyte Differentiation and Lipid Accumulation by Orengedokuto Treatment of 3T3-L1 Cultures. Phytother Res 2011 May 9. doi: 10.1002/ptr.3493. [Epub ahead of print]
1. Kaats GR, Blum K, Pullin D, Keith SC, Wood R. A randomized, double-masked, placebo-controlled study of the effects of chromium picolinate supplementation on body composition: A replication and extension of a previous study. Curr Ther Res. 1998;59(6):379-388. doi:https://doi.org/10.1016/S0011-393X(98)85040-6.
2. Docherty JP, Sack DA, Roffman M, Finch M, Komorowski JR. A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving. J Psychiatr Pract. 2005;11(5):302-314.
3. Anton SD, Morrison CD, Cefalu WT, et al. Effects of Chromium Picolinate on Food Intake and Satiety. Diabetes Technology & Therapeutics. 2008;10(5):405-412. doi:10.1089/dia.2007.0292.
4. Anderson RA, Cheng N, Bryden NA, et al. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes. 1997;46(11):1786-1791
5. Li Y, et al; Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes . J Transl Med. (2011)
6. Liu LZ, et al; The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP-activated protein kinase (AMPK)-mediated glucose uptake in muscle cells . Cell Signal. (2010)
7. Kim WS, et al; Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity . Am J Physiol Endocrinol Metab. (2009)
8. Lin W, Huang X, Zhang L, Chen D, Wang D, Peng Q, et al. (2012) BMS309403 Stimulates Glucose Uptake in Myotubes through Activation of AMP-Activated Protein Kinase. PLoS ONE7(8): e44570. https://doi.org/10.1371/journal.pone.0044570
9. Liu L-Z, Cheung SCK, Lan L-L, et al. Berberine modulates insulin signaling transduction in insulin-resistant cells. Mol Cell Endocrinol. 2010;317(1-2):148-153. doi:10.1016/j.mce.2009.12.027
10. Dong H, Wang N, Zhao L, Lu F. Berberine in the Treatment of Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis. Evidence-based Complementary and Alternative Medicine?: eCAM. 2012;2012:591654. doi:10.1155/2012/591654.
11. Godugu C, Patel AR, Doddapaneni R, Somagoni J, Singh M (2014) Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid. PLoS ONE 9(3): e89919. https://doi.org/10.1371/journal.pone.0089919
12. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung. 1995;45(8):872-874
13. Kim MS, et al; Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase . Nat Med. (2004)
14. Cheng PY, et al; Reciprocal effects of α-lipoic acid on adenosine monophosphate-activated protein kinase activity in obesity induced by ovariectomy in rats . Menopause. (2011)
15. Kanetkar P, Singhal R, Kamat M. Gymnema sylvestre: A Memoir. Journal of Clinical Biochemistry and Nutrition. 2007;41(2):77-81. doi:10.3164/jcbn.2007010
16. Pothuraju, R., Sharma, R. K., Chagalamarri, J., Jangra, S. and Kumar Kavadi, P. (2014), A systematic review of Gymnema sylvestre in obesity and diabetes management. J. Sci. Food Agric., 94: 834–840. doi: 10.1002/jsfa.6458.
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